Putative Protein Interactome Database

Following the completion of full genome sequences for several model organisms, protein interaction networks of some viral, prokaryotic and eukaryotic species have been established gradually. Many studies have already elucidated that the functional related proteins of different species were regulated in similar mechanism. In last decade, most of the protein interactions existed in yeast (S. cerevisiae), but few in other species. Via the strategies based on evolutionary conserved regions among living organisms, we could discover the interlogs between yeast and target organisms. In the same way, the paralogs existing in yeast also can provide clues to predict those may interact with others and to construct a comprehensive interaction map. The proteome of those organisms were used as alignment templates to identify novel genes in different species. Many studies also elucidate that the functional related proteins of different species were regulated in similar mechanism. This suggested the study strategies are feasible based on evolutionary conserved regions among living organisms, including yeast, worm, fly and human, etc. Accumulated sequences of genome projects will led us to extend our interests in uncovering interactomes in a comparative manner.